PHARMACEUTICAL FREEZE DRYER
Pharmaceutical Freeze Dryer & Lyophilizer Manufacturer and Supplier in India at affordable Price.
WHAT IS A PHARMACEUTICAL FREEZE DRYER?
The Pharmaceutical Freeze Dryer (Lyophilizer) is equipment that allows the drying of materials without the need to heat them. The physical principle involved in freeze-drying is sublimation, which is the direct passage from a solid to a gaseous state, without passing through the liquid state. For the process to take place, the frozen product is dried under a vacuum, without thawing. A pharmaceutical freeze dryer is high-tech equipment, which dehydrates by freezing (sublimation), keeping all the characteristics, nutrients, and physical structure of the products.
Pharmaceutical Vaccine Freeze Dryer For Vial Powder and Vaccine
Main Application : Vacuum freeze dryer working principle is derived from the vacuum state that uses the principle of sublimation and causes the water moisture content in pre-freezing of medicine. Medicine freeze drying goal is mainly achieved when water vapors are removed from the ice stage in ice ablation. The vacuum freeze dryer has refrigeration system, vacuuming system, dehumidification system & oil heating system equipped in a customized box structure. These box structures are divided into the form of Lab freeze dryer, Raw material freeze dryer, Pharmaceutical freeze dryer and Pilot model freeze dryer.
Freeze dried products are dry-shrinking, less water content, spongy, perfect in rehydration process, easy to transport, Easy to store at room temperature for a long shelf life after packaging. Freeze dried products are widely used for below purposes.
- Medicine pieces
- biological samples
- blood & fluid products
- Antibiotics
- Active substance
- Chemicals
- Pharmaceutical intermediates
- vaccines
FEATURES: PHARMACEUTICAL FREEZE DRYER
- User-friendly and environmentally friendly
- Forced-air cooling condensation type refrigeration system
- Cooling system and heating system with temperature control
- Made of stainless steel structure with mirror polished
- Water cooling control system
- Vacuum (Pressure) control system
- Accurate temperature control system
- Auto control of digital PID control
- Display of actual values during operation: temperature, vacuum & freeze-drying time
- Reliable refrigerant compressor with low noise
- CFC/HCFC free refrigerant system
WHAT IS FREEZE-DRYING?
Freeze-drying is the process of dehydration by sublimation, in this process the water contained in the products that are being freeze-dried passes directly from the solid to the gaseous state – without going through the liquid state. The main advantage of freeze-drying over conventional dehydration (by heating) is the maintenance of all the characteristics and properties, physical and nutritional structures of the product, that is, only the water is removed, which is why it is called the noble dehydration process.
Freeze-dried products can be preserved and stored without the need for any type of preservatives or low temperature, just add water and it will have all its characteristics untouched. To freeze-dry any product, it is necessary to develop a Freeze-drying Protocol that varies according to its composition and its molecular structure. The process in general terms is easy to understand, first, the product is frozen until the water in it is completely frozen (matured), then the product is placed in a vacuum chamber until the water is sublime, that is, go from solid state directly to gas. Depending on the case, it is possible to add heating in the equipment controlled by Auto-PID to speed up the process.
MODELS SPECIFICATIONS: PHARMACEUTICAL FREEZE DRYER
| Type | YS-PRO-10.0 | YS-PRO-13.0 | YS-PRO-16.0 | YS-PRO-20.0 |
| Drying capacity (Liter) | 200 | 260 | 320 | 400 |
| Shelf area(m²) | 9.72 | 12.96 | 15.84 | 19.80 |
| Shelf size(L*W*H)(mm) | 1200*900 | 1200*1200 | 1200*1200 | 1500*1200 |
| Useable Shelf No. | 9 | 9 | 11 | 11 |
| Vial loading quantity φ16 | 40000 | 56000 | 68000 | 80000 |
| φ22 | 20000 | 28000 | 34000 | 40000 |
| Inter. Shelf distance | 100 | 100 | 100 | 100 |
| Shelf ultimate cooling temperature(℃) | -55 | -55 | -55 | -55 |
| Condenser ultimate cooling temperature(℃) | -75 | -75 | -75 | -75 |
| Ultimate vacuum(Pa) | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 |
| Dimension(L*W*H)(mm) | 6000*1750*3800 | 6800*2000*3800 | 6800*2000*4200 | 7500*2000*4200 |
| Weight(Kg) | 10000 | 12500 | 15000 | 17500 |
| Power(KW) | 63.0 | 77.5 | 91.5 | 120.0 |
| Type | YS-PRO-25.0 | YS-PRO-30.0 | YS-PRO-40.0 | YS-PRO-50.0 |
| Drying capacity (Liter) | 500 | 600 | 800 | 1000 |
| Shelf area(m²) | 24.75 | 30.00 | 42.00 | 49.50 |
| Shelf size(L*W*H)(mm) | 1500*1500 | 2000*1500 | 2000*1500 | 2200*1500 |
| Useable Shelf No. | 11 | 10 | 14 | 15 |
| Vial loading quantity φ16 | 100000 | 120000 | 175000 | 200000 |
| φ22 | 50000 | 60000 | 85000 | 100000 |
| Inter. Shelf distance | 100 | 100 | 90 | 90 |
| Shelf ultimate cooling temperature(℃) | -55 | -55 | -55 | -55 |
| Condenser ultimate cooling temperature(℃) | -75 | -75 | -75 | -75 |
| Ultimate vacuum(Pa) | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 |
| Dimension(L*W*H)(mm) | 7200*3000*4200 | 7600*3000*4200 | 7600*3200*4500 | 9600*2300*4700 |
| Weight(Kg) | 20000 | 25000 | 30000 | 35000 |
| Power(KW) | 135.0 | 147.0 | 179.0 | 215.0 |
Optional Accessories
- Eutectic point tester
- Oil mist filter system
- Vacuum adjustment system
- Mobile phone APP monitoring system
- Automatic backfill/drainage system
- Imported vacuum pump
- Cold trap electrical heat defrosting
- Freeze drying finished judgement feature
- Vacuum pump anti-returned oil device
- data recorder
- backfill filter
- Automatic backfill and drainage control system
- capacitive vacuum gauge
- External hanging bottle device
PILOT Model – Freeze Dryer
Pilot freeze dryer is a small in-situ freeze-drying equipment. Yatherm Offers pilot production models with standard operating and Automatic Top pressing. It is used not only in pharma pilot workshops and small batch production but also in the food or medicinal freeze-drying process. Situ freeze-drying technology is one of the advanced international constructer designs which avoid contamination during materials transfer and realize the dry sublimation automatically.
The pilot freeze dryer is with rack heating programmable function and memory freeze-drying curve which convenient users to get the freeze-drying production technology. it is divided into standard and gland types.
Models: Technical Matrix
| Model | YS – FD20S (Standard) |
YS – FD20T (Stoppering) |
YS – FD30S (Standard) |
YS – FD30T (Stoppering) |
|
| Freeze Drying Area | 0.3m² | 0.2m² | 0.4 m² | 0.3 m² | |
| Shelf Temperature | -50℃~+70℃(no-loading) | ||||
| Cold Trap Temperature | <-75℃(no-loading) | ||||
| Vacuum Degree | ≤5Pa(no-loading) | ||||
| Water Capture Capacity | ≥6kg | ≥8kg | |||
| Cold Trap Volume | 14L | / | 26L | ||
| Cold Trap Size (Diameter*H) | Φ200*460mm | / | Φ320*520mm | ||
| Drying Chamber Size (W*D*H) | 330*325*470mm | 340*500*420mm | 480*380*540mm | ||
| Shelf & Tray Size (W*D*H) |
Shelf: 400*270*18mm Tray: 395*265*25mm |
Shelf: 300*340*18mm Tray: 295*335*25mm |
|||
| Qty. Of Shelf & Tray | Shelf: 3+1; Tray: 3 | Shelf: 2+1; Tray: 2 | Shelf: 4+1; Tray: 4 | Shelf: 3+1; Tray: 3 | |
| Sample Loading Capacity (Liquid) | 3L | 2L | 4L | 3L | |
| Height Between Trays | 70mm | 50mm | 70mm | ||
| Tray Temperature Difference | ±1℃ | ||||
| Refrigerant | R404A + R23 | ||||
| Condenser Cooling Mode | Air cooling | ||||
| Defrost Mode | Electric defrosting | Natural defrosting(optional electric defrosting) | Electric defrosting | ||
| Stoppering Mode | / | Manual | / | Automatic | |
| Total Qty. Of Vial | Φ20mm | / | 440 | / | 654 |
| Φ18mm | / | 868 | / | 1200 | |
| Φ12mm | / | 1554 | / | 2187 | |
| Vacuum Pump | 4L/S(14.4m³/h) | 6L/S(22m³/h) | |||
| Electric Defrosting Consumption | 800W | 800W | / | 1000W | |
| Silicone Oil Heating Rods Consumption | 800W | 800W | 1000W | 1000W | |
| Hydraulic Pressure Station Consumption | / | 500W | / | 1000W | |
| Total Consumption | 3KW | 3KW | 4.5KW | 5.5KW | |
| Power Supply | AC220V, 50Hz/60Hz(single phase) | ||||
| Main Body Weight | 300kg | 400kg | |||
| External Size (W*D*H)mm |
840*750*1580 | 920*780*1350mm | 1260*850*1420mm | ||
| Packing Size (W*D*H)mm/ Gross Weight |
Main Body | 980*860*1720/400kg | 980*860*1720/470kg | 1100*980*1570/450kg | 1440*1070*1720/651kg |
| Vacuum Pump | 950*420*500(37kg) | 790*340*460(57kg) | 790*300*470(52kg) | ||
Models: Technical Matrix for Big Chamber Size
| Model | YS – FD50S (Standard) |
YS – FD50T (Stoppering) |
YS – FD100S (Standard) |
YS – FD100T (Stoppering) |
|
| Freeze Drying Area | 0.7m² | 0.5m² | 1.04 m² | 1.15m² | |
| Shelf Temperature | -50℃~+70℃(no-loading) | ||||
| Cold Trap Temperature | <-75℃(no-loading) | ||||
| Vacuum Degree | ≤5Pa(no-loading) | ||||
| Water Capture Capacity | ≥10kg | ≥15kg | |||
| Cold Trap Volume | / | 70L | |||
| Cold Trap Size (Diameter*H) | / | Φ400*560mm | |||
| Drying Chamber Size (W*D*H) | 410*510*590mm | 620*510*580mm | 410*580*520mm | 700*590*760mm | |
| Shelf & Tray Size (W*D*H) |
Shelf: 480*360*18mm Tray: 475*355*25mm |
Shelf: 410*410*18mm Tray: 405*405*25mm |
Shelf: 480*360*18mm Tray: 475*355*25mm |
Shelf: 480*600*18mm Tray: 475*595*25mm |
|
| Qty. Of Shelf & Tray | Shelf: 4+1; Tray: 4 | Shelf: 3+1; Tray: 3 | Shelf: 6+1; Tray: 6 | Shelf: 4+1; Tray: 4 | |
| Sample Loading Capacity (Liquid) | 7L | 5L | 10L | 11L | |
| Height Between Trays | 70mm | 100mm | |||
| Tray Temperature Difference | ±1℃ | ||||
| Refrigerant | R404A + R23 | ||||
| Condenser Cooling Mode | Air cooling | ||||
| Defrost Mode | Natural defrosting(optional electric defrosting) | Electric defrosting | Electric defrosting | Electric defrosting | |
| Stoppering Mode | / | Automatic | / | Automatic | |
| Can Load Vials Qty | Φ20mm | / | 1050 | / | 2460 |
| Φ18mm | / | 2058 | / | 4788 | |
| Φ12mm | / | 3075 | / | 8624 | |
| Vacuum Pump | 8L/S(29m³/h) | 15L/S(54m³/h) | |||
| Electric Defrosting Consumption | / | 1000W | 1500W | ||
| Silicone Oil Heating Rods Consumption | 1000W | 1600W | |||
| Hydraulic Pressure Station Consumption | / | 1000W | / | 1500W | |
| Total Consumption | 5.5KW | 6.5KW | 6.5KW | 7.5KW | |
| Power Supply | AC380V, 50Hz/60Hz(three phase); BK-FD50S: AC220V, 50Hz/60Hz(single phase) | ||||
| Main Body Weight | 600kg | 800kg | 700kg | 1000kg | |
| External Size (W*D*H)mm |
1000*850*1420 | 1490*850*1620 | 1170*830*1665 | 1640*1100*1630 | |
| Packing Size (W*D*H)mm | Main Body | 1130*980*1620/565kg | 1600*1040*2040/800kg | 1320*990*1855/900kg | 1800*1250*2100/1200kg |
| Gross Weight | Vacuum Pump | 790*330*445(73kg) | 830*370*600(88kg) | 785*455*300(95kg) | 800*500*500(70kg) |
USES: PHARMACEUTICAL FREEZE DRYER
Companies often use pharmaceutical lyophilization (freeze-drying) to extend the shelf life of products such as vaccines, medicines, and other health care products. By removing water from the material and sealing the material in a vial, the material can be easily stored, shipped, and then reconstituted to its original form for injection. A Freeze dryer is used in several areas, and most commonly in biological products, pharmaceuticals. For example: preserving plants, herbs, and organic compounds, antibiotics, bacteria, serums, vaccines, diagnostic drugs, products containing proteins and biotechnology, human and animal cells and tissues of other species, chemical products, solid or liquid medicines.
ADVANTAGES: PHARMACEUTICAL FREEZE DRYER
Pharmaceutical products frozen through our lyophilizer have excellent advantages, which are described below:
- The balance between vacuum, cold, and heat
- Keep 100% of the characteristics, nutrients, and physical structures
- Keeps its natural shape
- Your color is retained
- Does not change the nutritional aspects
- It has a fresh taste for a longer time
Chamber
Pilot model freeze dryer chambers are rectangular in shape equipped with SS 304 removable shelves, plexi glass door & contact parts made up of ss316. Shelves has a temperature range of -60°C to +70°C ±1°C & Fast cooling function ranges +20℃ to -40℃ within an hour. This chamber has pre-freezing, & vacuum drying in same chamber without any human assistance.
For pharmaceutical industry and bio field applications oil circulation type heating is preferred in place of electric heating. Oil circulation type heating is more accurate, precisely control & as per the Pharmaceutical standards. Shelves heating rate (Ramp rate) can be controlled by PLC that provides a safe voltage system & uniform temperature for samples. Cross type of walls are designed according to the GMP standards.
Condenser (cold trap)
We design large capacity condenser made up of stainless steel 316 grade for pharmaceutical freeze dryers. Lowest condenser range of temperature is -80 degree Celsius with silicon oil based machine, where electric heating system has lowest temperature range -55 degree Celsius. Cold trap systems are cylindrical in shape, has independent function with ice removal capacity to ensure great working performance. Chambers condenser’s has innovative gas diversion technology, ice catching feature & electric heating.
Refrigeration System
Pharmaceutical freeze dryers operates at -86 degree Celsius, achieving -86 degree Celsius temperature possible with dual stage cooling technology. We prefer hermetic sealed, CFC free, environmental friendly Tecumseh & Danfoss compressor. These compressors has power full cooling, low noise, economic, highly stable & less power consumption. Our refrigeration system has Brazed plated heat exchanger, Danfoss brand pressure controller & valve. Air cooled refrigeration systems are easy to operate, accurate and work without additional cooling device in room.
Control System
Yatherm Pharma Lyophilizers has 7 inches and 10 inches HMI with PLC that works in automatic , semi-automatic and manual modes. PLC has 32 inbuilt programs and each program has 35 segments, graphs and data can be stored and modified in real time. PLC has many features for controlling, modification and recording.
- Shelf temperature setting
- Vacuum level Setting
- Data Recording
- USB interface
- Software for controlling from remote way
- Sensor Calibration
- Audio and visual Alarm system for High/Low Temperature, Door open, fault diagnosis & maintenance
- Password protection – Three level Password security
Vacuum System
Two stage automatic adjustable rotary vane vacuum pump has ultimate vacuum capacity that can reach to 1 pascal in order to achieve highest level of drying. High quality vacuum pump used for drying purpose that reaches to 10 pascals in less than 20 minutes with a leakage rate of less than 10 Pa·l / sec.
Safety Protection
- Electrical system has logic interlocking
- Safety Alarm for vacuum and temperature
- Electric power safety protection
- Sublimation process protection in case of power fail
- Material safety during sublimation
- Automatic cut off heating in case of vacuum leakage
- Data recorded in case of power fails
- CE/ISO 9001 13485 14001 certificated, conforms to GMP standard
WHY BUY YOUR PHARMACEUTICAL FREEZE DRYER WITH YATHERM SCIENTIFIC?
All Yatherm Scientific Freeze Dryer models have the technology to be competent and able to work in the areas of food, pharmaceuticals, research, veterinary medicine, cosmetics, and teaching. But before buying, do you really know what is the right freeze dryer for your needs and its details & advantages? The Yatherm Scientific’s main objective is to help you to have the best and make the best use of a pharmaceutical freeze dryer (lyophilizer). If you need to Pharmaceutical Freeze Dryer, our team is to help you with both the protocol and the adaptation of equipment for your needs, whether industrial or scientific research. And Full support to customers in pre-and post-sales. Would you like to request a quote? Contact us!
- We offer Machine according to the international standards and regulations like EU cGMP, WHO GMP, UK MHRA etc.
- We can send our 20 year experience engineer team to give installation and validation.
- We offer all Validation documents (DQ,IQ,PQ,OQ) with the machine
- We provide working videos of installation, operation & complete working procedure.
- We offer free training to the buyer.
- We offer two years of warranty and life time service support.
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